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KMID : 0381120130350030327
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Genes and Genomics
2013 Volume.35 No. 3 p.327 ~ p.334
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Expression pattern of genes involved in maternal immune regulation during the peri-implantation and midgestation in Meishan pigs
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Li Xiaoping
Zhang Zongping
Huang Jiangnan
Su Lijie
Zhu Mengjin
Yu Mei
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Abstract
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In pigs, complex molecular cross-talk between the mother and embryo(s) especially maternal immunotolerance at the maternal-fetal interface has been postulated to play important roles on embryo/fetal loss during the peri-implantation and midgestation. In this study, we collected the endometrium samples in implantation sites at gestational day 15 (gd15), 26 (gd26)) and 50 (gd50) from Meishan pigs to evaluate the contribution of the genes participating in immune response by using porcine Affymetrix GeneChip.The results showed that totally 68 immune related genes showed significantly differential expression at three stages, and the expression of these genes underwent drastic changes during the peri-implantation period (between gd15 and gd26). The identified genes including IL6 proinflammatory cytokine family, inflammatory chemokines (CCL28), IGF/IGFBP system, growth factors (FGF7) and adhesion molecules (ITGB3, PCDH15) may prove valuable for further investigations of porcine prenatal mortality.
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KEYWORD
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Maternal immunotolerance, Prenatal mortality, Porcine endometrium, Peri-implantation
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